Enhanced Hyperthermia Therapy By Magneto-photothermal Dual-mode Treatments In Mwcnts/mn0.5zn0.5fe2o4 Nanohybrids

• By: LI, Lixian (Chongqing University Cancer Hospital)
• Co-author(s): Ph. D Kaiming Shen (Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Chongqing, China)
  Ph. D Jingxiang You (Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Chongqing, China)
  Prof Lixian Li (Department of Pharmacy, Chongqing University Cancer Hospital, Chongqing, China)
  
• Abstract:

  Alternative cancer treatments such as photothermal therapy (PTT) and magnetic hyperthermia (MHT) techniques have been studied to show promising potential as supplementary modalities. However, such techniques have their own limitations, for instance, high magnetic fluid concentration is required for the MHT, while the PTT has limitations in the treatment of deep-seated tumors due to low light penetration. Here, we report the development of MWCNTs/Mn0.5Zn0.5Fe2O4 (MZFC) hybrids for magneto-photothermal dual-mode cancer therapy. The obtained specific loss power (SLP) of the MZFC hybrids is found at least 1 order of magnitude higher, with improvement from ~ 19 W/g to 225 W/g, under the excitation of both an AMF of 6.4 kA/m and simultaneous NIR laser of 0.5 W/cm² irradiation. The synergistic exploitation of the photothermal and magnetic properties of MZFC effectively reduces the amplitude of the magnetic field and the NIR laser power density. Our in vitro cell experiments confirmed that the thermal effects mediated by the MZFC after endocytosis delivered enhanced cytotoxicity in the presence of dual excitation of NIR laser and AMF. These functional nanohybrids show promising potential for cancer therapy by using the PTT-MHT dual-mode magneto-photothermal techniques.